I as in Ithaca' The term 'I as in Ithaca' is a crossword solution that can be filled in with the four-letter word 'IOTA'. IOTA is the ninth letter of the Greek alphabet and is often used to represent a small amount or quantity. It is also used in mathematics and science to represent a very small number or fraction. In literature, it is sometimes used to symbolize something insignificant or unimportant. The phrase 'I as in Ithaca' is derived from Homer's epic poem The Odyssey, in which Ithaca is the home of the hero Odysseus.