The term 'HOW MUCH TO TAKE' can be answered by two crossword solutions: DOSE (4 letters) and DOSAGE (6 letters). DOSE is a medical term that refers to the amount of medicine or drug prescribed to be taken at one time. DOSAGE is the total amount of medicine or drug that is prescribed to be taken over a period of time. Both terms are used to describe the amount of medication that should be taken in order to achieve the desired effect.