How Aspirin is taken can be summarized as ORALLY. Aspirin is a medication used to reduce pain, fever, and inflammation. It is typically taken ORALLY, either in pill form or as a liquid suspension. Aspirin is also available in topical forms, such as creams and gels, but these are not as commonly used. Taking aspirin ORALLY is the most common way to take the medication, and it is important to follow the instructions on the packaging for the best results.