The term 'HOLY REGION' can be seen in a crossword puzzle as three separate words: 'HOLY, ' 'REGION, ' and 'SEE' (3 letters). The word 'HOLY' is often used to describe something that is sacred or divine, while 'REGION' refers to an area or part of the world. The word 'SEE' is a verb meaning to perceive with the eyes or to understand. Therefore, the phrase 'HOLY REGION' could refer to a place that is considered sacred or divine, or an area that is understood to have spiritual significance.