The term 'HIGH SCHOOL BREAKOUT' can be solved with the four-letter word 'ACNE'. ACNE is a common skin condition that affects many teenagers during their high school years. It is caused by an overproduction of oil in the skin, which can lead to clogged pores and the formation of pimples. ACNE can cause physical and emotional distress for those affected, making it a fitting solution for the term 'HIGH SCHOOL BREAKOUT'.