A heart problem is a medical condition that affects the heart and can be caused by a variety of factors. The three crossword solutions for the term 'heart problem' are ACHE (4 letters), ANGINA (6 letters), and MURMUR (6 letters). ACHE is a general term for pain, usually localized in one area of the body. Angina is chest pain caused by reduced blood flow to the heart. MURMUR is an abnormal sound heard during a heartbeat, which can indicate a heart problem.