The crossword solution for the term 'Having a lot to lose, maybe?' is 'OBESE' (5 letters). OBESE is a medical term used to describe someone who is significantly overweight and has an excessive amount of body fat. It is usually associated with health risks such as heart disease, stroke, diabetes, and certain types of cancer. People who are OBESE may have a lot to lose in terms of their health, which is why it is important to maintain a healthy lifestyle.