Hamlet and Ophelia are two of the most iconic characters in William Shakespeare's play, 'HAMLET'. HAMLET is the Prince of Denmark and the protagonist of the play, while Ophelia is a young noblewoman of Denmark and a major character in the story. The crossword solutions for the term HAMLET OR OPHELIA are DANE (4 letters) and ROLE (4 letters). DANE refers to the fact that both characters are from Denmark, while ROLE refers to their respective roles in the play.