GUSSIES (UP) is a term used to describe a group of people, usually friends or family. The crossword solutions for GUSSIES (UP) are PREENS (6 letters), DUDES (5 letters), and SPRUCES (7 letters). PREENS means to groom oneself, DUDES means a man or boy, and SPRUCES means to make something look neat and tidy. Therefore, GUSSIES (UP) can be interpreted as a group of people who take care of their appearance and make sure they look neat and tidy.