Gridiron setback is a term used to describe the losses and penalties that can occur during a game of American football. The term 'LOSS' (4 letters) refers to the team's score being lower than the opposing team's score, resulting in a loss for the team. The term 'FACEMASKPENALTY' (15 letters) refers to a penalty that occurs when a player grabs an opposing player's facemask, which results in a 15-yard penalty.