The term 'Great White Hunter' is a reference to the character of Captain Ahab from Herman Melville's novel Moby-Dick. Ahab was a whaling captain who was obsessed with hunting down the white whale Moby-Dick. He was known for his single-minded determination and his willingness to risk his own life in pursuit of his goal. The crossword solution for this term is 'AHAB', which is an acronym for the character's full name, 'Captain Ahab'.