The term 'Great Pain' can be described by three words: ANGUISH (7 letters), AGONY (5 letters), and THROE (5 letters). ANGUISH is a deep, intense emotional pain or suffering, often caused by mental or physical distress. AGONY is a state of intense suffering, both physical and mental, and is usually associated with extreme physical pain. Lastly, THROE is an archaic word for a sharp, intense pain or suffering. All three words describe the same concept of great pain, but each word has its own unique connotation.