The Great Lakes State is Ohio, which has four letters. Ohio is a state located in the Midwestern United States, bordered by Lake Erie to the north, Pennsylvania to the east, West Virginia to the southeast, Kentucky to the southwest, and Indiana to the west. It is the seventh most populous state in the United States and the 34th largest by area. Ohio is known as the 'Buckeye State' and is home to many major cities, including Cleveland, Cincinnati, and Columbus.