The Great Lakes Region is a region in North America that consists of the five Great Lakes and their surrounding areas. It includes the states of Ohio and Ontario, which are both represented in the crossword solutions by their four-letter and seven-letter abbreviations respectively. Ohio is the 34th most populous state in the United States, while Ontario is the most populous province in Canada. The Great Lakes Region is an important economic hub for both countries, with many industries relying on the lakes for transportation and resources.