The term 'Grand Tour Setting' refers to a journey through Europe that was popular among wealthy young men in the 17th and 18th centuries. The term is derived from the French phrase 'grand tour, ' which translates to 'great journey.' The Grand Tour was a rite of passage for these young men, who would travel to various European cities to experience the culture, art, and architecture of the continent. The six-letter solution to this crossword puzzle is 'Europe, ' which was the primary destination for these grand tours.