_ _ _ _' The crossword solution for the term GAME WITH COLONEL MUSTARD is CLUE, a four letter word. CLUE is a popular board game created in 1949 by Anthony E. Pratt. The game involves players trying to solve a murder mystery by gathering clues and making accusations. The game is set in a mansion and the characters are Colonel Mustard, Miss Scarlet, Professor Plum, Mrs. White, Mr. Green, and Mrs. Peacock.