Gambler's Mecca is a term used to describe three of the world's most popular gambling destinations: Reno, Nevada, Las Vegas, Nevada, and Monte Carlo, Monaco. Reno is known for its casinos, hotels, and entertainment, while Las Vegas is renowned for its vibrant nightlife and extravagant casinos. Monte Carlo, located in Monaco, is a luxurious destination with a rich history of gambling. All three cities are considered to be the ultimate gambling destinations for gamblers around the world.