From Square One Again' is a phrase that refers to starting over from the beginning. It implies that all previous efforts have been forgotten or abandoned, and that the task at hand must be approached as if it were being done for the first time. The term is often used in reference to business ventures, where a company may need to restart its operations or strategy in order to achieve success. In this case, the crossword solution for the term FROM SQUARE ONE AGAIN is ANEW, which means 'starting over from the beginning.'