The term 'TSETSE' is a 6-letter fly that carries sleeping sickness, also known as African trypanosomiasis. It is a vector-borne disease caused by the protozoan parasite Trypanosoma brucei, which is transmitted to humans and other animals by the bite of an infected TSETSE fly. The disease is endemic in 36 countries in sub-Saharan Africa, where it is responsible for significant mortality and morbidity. Treatment is available, but prevention is the best way to reduce the spread of the disease.