The term 'FIRST GAME' can be solved by the crossword solution 'OPENER' (6 letters). The term 'OPENER' is often used to refer to the first game of a series, such as the first game of a sports season or the first game of a tournament. It can also refer to the first game of a video game series, or the first game of a board game series. In any case, the term 'OPENER' is used to describe the first game in a series.