The Mayo Clinic is a world-renowned medical center located in Rochester, Minnesota. It is one of the most famous clinics in the world, known for its research and treatment of a wide range of medical conditions. The clinic was founded in 1889 by Dr. William Worrall Mayo and his two sons, Dr. William James Mayo and Dr. Charles Horace Mayo. It has since grown to become one of the largest and most respected medical centers in the world.