The answer to the crossword for the term 'FAMILY GUY WIFE' is Lois, which is a four-letter word. Lois is the wife of Peter Griffin in the popular animated television series Family Guy. She is a stay-at-home mother and housewife who cares for her children and supports her husband's antics. Lois is a strong-willed, independent woman who often finds herself in the middle of her family's outrageous adventures.