The crossword solution for the term 'FAMILY GUY MOTHER' is 'LOIS', which is a four-letter word. Lois Griffin is the mother of the Griffin family in the popular animated sitcom 'Family Guy'. She is the wife of Peter Griffin and the mother of Meg, Chris, and Stewie. Lois is a stay-at-home mom who is often seen cooking and cleaning for her family. She is also known for her sharp wit and sarcastic sense of humor.