The term 'DESPICABLE ONE' can be broken down into nine crossword solutions: TOAD (4 letters), WORM (4 letters), CAD (3 letters), RAT (3 letters), CUR (3 letters), TWERP (5 letters), FIEND (5 letters), LOUSE (5 letters), and WRETCH (6 letters). These words are all used to describe someone who is considered to be despicable, or worthy of contempt. A TOAD is a type of amphibian that is often seen as slimy and unattractive. A WORM is a small, wriggling creature that is often seen as disgusting. A CAD is a man who behaves in an immoral or dishonorable way. A RAT is a rodent that is often seen as dirty and sneaky. A CUR is a mean or cowardly person. A TWERP is an annoying or insignificant person. A FIEND is a cruel or wicked person. A LOUSE is a small, wingless insect that lives on the bodies of humans and animals. A WRETCH is a miserable or unfortunate person. Finally, a so-and-so is a contemptuous term for someone whose name is not known or remembered.