A Despicable Fellow is someone who is considered to be contemptible, mean, or despicable. The term can be used to describe a person who is unkind, selfish, and generally unpleasant. Two words that are often used to describe a Despicable Fellow are TWERP (5 letters) and ROTTER (6 letters). TWERP is an informal term for someone who is annoying or foolish, while ROTTER is a slang term for someone who is morally reprehensible.