The crossword solution for the term DEPLETE (OF) is SAP, which stands for System Application and Products. SAP is a software suite developed by German company SAP SE that provides enterprise resource planning (ERP) and customer relationship management (CRM) applications. It is used by businesses to manage their operations, such as accounting, inventory, and human resources. SAP is one of the most popular ERP systems in the world, with over 400, 000 customers in more than 180 countries.