A defiant response is a reaction that is intended to show resistance or opposition. The crossword solutions for this term are NEVER (5 letters), ASIF (4 letters), CANTOO (6 letters), and MAKEME (6 letters). NEVER is an adverb meaning not ever, while asif is an informal way of saying as if. Cantoo is a combination of the words can and do, and makeme is a combination of the words make and me. Together, these words form a phrase that conveys a strong sense of defiance and refusal.