A cynic response is a negative or sarcastic remark that is often used to express disbelief or disdain. The crossword solutions for the term 'Cynic Response' are SNEER (5 letters), DIOGENES (8 letters), and ISM (3 letters). A SNEER is a facial expression of contempt or derision, while DIOGENES was an ancient Greek philosopher who was known for his extreme cynicism and asceticism. An ISM is a suffix used to denote a belief or doctrine, and in this case it could refer to the philosophical school of Cynicism.