The term 'Cranium Contents' refers to the contents of the skull, which is the bony structure that encloses and protects the BRAIN. The crossword solution for this term is 'BRAIN, ' which is a five-letter word. The BRAIN is the most important organ in the human body and is responsible for controlling and coordinating all of the body's activities. It is composed of billions of neurons that communicate with each other to process information and generate thoughts, feelings, and behaviors.