Cortisone is a STEROID hormone produced by the adrenal cortex in response to stress. It is used to treat a variety of conditions, including allergies, asthma, and arthritis. Cortisone is also used to reduce inflammation and swelling, and can be taken orally or injected directly into the affected area. Cortisone has been used for many years to treat a variety of medical conditions, and is still widely used today.