Lex Luthor is a comic book villain created by Jerry Siegel and Joe Shuster in 1940. He is the archenemy of Superman and is one of the most iconic villains in comic book history. Lex Luthor is a genius-level intellect, a wealthy businessman, and a power-hungry megalomaniac. He has been featured in various media adaptations of the Superman franchise, including television series, films, and video games. The three-letter solution to the crossword for the term 'Comic Villain Luthor' is LEX.