The Colombia River is a major river in South America, flowing through Colombia, Venezuela, and Ecuador. It is the largest river in Colombia and is fed by several tributaries, including the Orinoco (7 letters), Cali (4 letters), PANAMA (6 letters), Peru (4 letters), Bogota (6 letters), and PESO (4 letters). The Colombia River is an important source of water for the region and provides a vital transportation route for goods and people.