The term CHANGE YOUR GENES can be solved by the crossword solution MUTATE, which is a 6 letter word. MUTATE is a biological term that refers to a CHANGE in the genetic material of an organism. This CHANGE can be caused by environmental factors such as radiation or chemicals, or it can be a spontaneous mutation. Mutations can lead to changes in the physical characteristics of an organism, and can even be passed down to future generations. Therefore, when we talk about changing our genes, we are referring to the process of mutation.