The term 'cause wrinkle' can be broken down into three crossword solutions: IRON (4 letters), Botox (5 letters), and RETINA (6 letters). IRON is a chemical element that is used to create a variety of products, including clothing irons. Botox is a type of cosmetic treatment that involves injecting a toxin into the skin to reduce wrinkles. RETINA is a layer of tissue in the eye that helps to focus light and is often damaged by aging, leading to wrinkles.