The Carolina River is a river located in the southeastern United States. It is formed by the confluence of the Peedee and Pedee rivers in South Carolina, and then flows into the Santee River in North Carolina. The Peedee River is a tributary of the Great Pee Dee River, which is a tributary of the Waccamaw River. The Pedee River is a tributary of the Little Pee Dee River, which is also a tributary of the Waccamaw River. The Santee River is a tributary of the Cooper River, which is a tributary of the Atlantic Ocean.