The term 'Cactus with Buttons' refers to two species of cacti, PEYOTE (Lophophora williamsii) and MESCAL (Echinomastus johnsonii). PEYOTE is a small, spineless cactus native to Mexico and the southwestern United States, and is known for its psychoactive alkaloids. MESCAL is a larger, spiny cactus found in the Chihuahuan Desert of northern Mexico and the southwestern United States, and is also known for its psychoactive alkaloids. Both species are used in traditional spiritual ceremonies by Native American tribes.