The term 'Biggest Little City in the World' is often used to refer to Reno, Nevada. Reno is a city in the western United States, located in the state of Nevada. It is known for its casinos and nightlife, as well as its proximity to Lake Tahoe and the Sierra Nevada mountains. The term 'Biggest Little City in the World' is a reference to the fact that Reno is a relatively small city, but has a large population and a vibrant culture.