The term 'Big Twelve Powerhouse' refers to the University of KANSAS, a member of the Big 12 Conference. The school is located in Lawrence, KANSAS and is known for its strong athletic programs, particularly in basketball. KANSAS has won three NCAA Division I Men's Basketball Championships and has been a consistent contender in the Big 12 Conference. The school is also well-known for its academic excellence, having produced numerous Nobel Prize winners and other distinguished alumni.