The two crossword solutions for the term 'Big Name in Comedy' are LENO (4 letters) and Lucy (4 letters). Jay LENO is an American comedian, actor, writer, producer, and television host who was the host of NBC's The Tonight Show from 1992 to 2014. Lucille Ball was an American actress, comedian, model, film studio executive, and producer. She was best known as the star of the self-produced sitcoms I Love Lucy, The Lucy–Desi Comedy Hour, The Lucy Show, and Here's Lucy.