The term BIG ___ (DRUG COMPANIES) can be solved by the word 'PHARMA', which is a 6 letter word. Pharmaceutical companies, also known as pharma companies, are large corporations that research, develop, manufacture and market drugs and medications. They are responsible for the production of many of the medicines used to treat illnesses and diseases. Pharma companies are some of the largest and most influential companies in the world, and their products have a major impact on public health.