The crossword solution for the term 'BE DOWN WITH SOMETHING' is AIL, which is an abbreviation for 'AILMENT'. An AILMENT is a physical or mental illness, disorder, or condition that causes discomfort or distress. It can refer to any type of medical condition, from minor illnesses such as a cold to more serious conditions like cancer. To be down with something means to accept it or be in agreement with it. Therefore, the phrase 'be down with something' can be used to describe someone who is accepting of an AILMENT or illness.