The term 'Architect of Saint Paul' can be broken down into four crossword solutions: TARSUS (6 letters), DOMED (5 letters), WREN (4 letters), and CATHEDRAL (9 letters). TARSUS was the birthplace of Saint Paul, a major figure in the New Testament. Christopher WREN was an English architect who designed St. Paul's CATHEDRAL in London, which is DOMED and considered one of the most iconic buildings in the world. The CATHEDRAL of Saint Paul in Minnesota was designed by architect Emmanuel Louis Masqueray and is the namesake of the city.