The birthplace of Apollo is a combination of three answers from the crossword puzzle. The first answer is Delos, a Greek island in the Aegean Sea, which was an important religious center in ancient Greece and was believed to be the birthplace of Apollo. The second answer is MOON, which refers to the fact that Apollo was the god of the MOON in Greek mythology. The third answer is Lem, which is a reference to the Lemnian tribe, who were said to have been the first people to worship Apollo.