The Ancient Instrument crossword solutions are LYRE (4 letters), Rebec (5 letters), and Panpipes (8 letters). The LYRE is an ancient stringed instrument that was used in Ancient Greece and Mesopotamia. It was typically made of wood and had strings stretched across it. The Rebec is a bowed string instrument that originated in the Middle Ages. It was popular in Europe and the Middle East and was usually made of wood with a curved neck. The Panpipes are a set of pipes of different lengths that are played by blowing across the top of them. They were used in Ancient Greece and Rome and were often made of reeds or bamboo.