Ancient Buffalo is a term used to describe an extinct species of buffalo that lived in North America during the Pleistocene epoch. The scientific name for this species is Bison antiquus, and it is also known as the ANOA, which is a four-letter word that is commonly used as a crossword solution. Ancient Buffalo were much larger than modern buffalo, and they were hunted by early humans for their meat and hides. They were also an important part of the ecology of the region, providing food for predators such as wolves and bears.