The term 'AMES' STATE' is a crossword solution for the state of Iowa. Iowa is a state located in the Midwestern United States, bordered by the Mississippi River to the east and the Missouri River and Big Sioux River to the west. It is the 26th most populous state in the United States and the 30th most extensive in terms of total area. The capital of Iowa is Des Moines, which is also the most populous city in the state.