The term 'American Aloe' refers to three different plants: AGAVE (5 letters), MAGUEY (6 letters), and Centuryplant (12 letters). AGAVE is a genus of monocots native to the hot and arid parts of the Americas, ranging from the Southwestern United States to South America. MAGUEY is a species of AGAVE native to Mexico and Central America. Centuryplant is a species of AGAVE native to the southwestern United States and northern Mexico. All three plants are succulents and have been used for centuries for their medicinal properties.