The crossword solution for the term 'alienate from friendship' is 'ESTRANGE'. To ESTRANGE someone is to cause them to become distant or disconnected from a person or group, often due to a disagreement or conflict. This can lead to a breakdown of the relationship and a feeling of alienation. In the context of friendship, estrangement can occur when two people have a disagreement or conflict that causes them to drift apart and no longer be close friends.