The crossword solutions for the term 'AFRICA ISLAND LARGEST' are SAO (3 letters) and SAHARA (6 letters). The largest island in Africa is Madagascar, but the second largest is Sao Tome and Principe, an island nation off the western coast of Central Africa. The SAHARA Desert is the largest desert in the world, covering much of North Africa. It stretches from the Red Sea in the east to the Atlantic Ocean in the west.