The term 'Africa Disease' can be broken down into two crossword solutions: MONO (4 letters) and TSETSE (6 letters). MONO is short for mononucleosis, which is a viral infection that causes fatigue, fever, and swollen lymph nodes. It is also known as the 'kissing disease' because it is spread through saliva. TSETSE is a type of fly found in Africa that carries a parasite that causes sleeping sickness. Sleeping sickness is a potentially fatal disease that affects the central nervous system and is transmitted through the bite of an infected TSETSE fly.